Morphogenesis of a branching structure

Across TCGA cell cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZD3, FBXO16, and AKAP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FZD3 grouped by Morphogenesis of a branching structure-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FZD3 →	+0.960	+1.125	<.001	<.001	3	4
SKIN	FBXO16 →	+0.527	+0.711	.004	.002	3	4
LUNG_SCLC	AKAP7 →	+1.541	+0.644	<.001	.007	3	3
LUNG_SCLC	INKA2 →	-1.417	-0.650	.008	.006	3	3
LUNG_SCLC	EML6 →	-1.658	-0.682	.002	.004	3	3
OVARY	RAI1 →	+0.736	+0.689	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FZD3 by Morphogenesis of a branching structure activity — SKIN

Explore this box plot interactively →