Morphogenesis of a branching structure

Across TCGA cell cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO2, DDIT3, and CUX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO2 grouped by Morphogenesis of a branching structure-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGO2 →	+0.118	+0.059	.002	.007	3	5
LUNG_NSCLC_LUAD	DDIT3 →	-0.163	-0.080	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CUX1 →	-0.150	-0.080	.006	.005	3	4
PANCREAS	RAB6C-AS1 →	-0.181	-0.079	.003	.001	3	4
LUNG_SCLC	CRNN →	-0.429	-0.077	.006	.007	3	4
LARGE_INTESTINE	GPR149 →	-0.188	-0.109	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO2 by Morphogenesis of a branching structure activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →