Morphogenesis of a branching structure

Across TCGA cell cohorts, RNA activity of the Morphogenesis of a branching structure pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSZ, PTPRB, and PRSS3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a branching structure activity versus CTSZ in CNS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CTSZ →	+4.055	+1.078	.003	.005	2	8
KIDNEY	PTPRB →	+2.174	+0.251	<.001	<.001	3	6
OESOPHAGUS	PRSS3 →	+3.422	+1.125	<.001	<.001	3	4
OESOPHAGUS	SHH →	+0.882	+1.334	<.001	.002	3	4
CNS	NOXA1 →	+0.544	+0.687	.002	.006	3	4
OESOPHAGUS	FAM107B →	+2.024	+0.945	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001763 vs CTSZ — CNS

Explore this scatter interactively →