Organ induction

Across TCGA patient cohorts, RNA activity of the Organ induction pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT1, FOXM1, and TACC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organ induction activity versus SOAT1 in PDAC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SOAT1 →	-0.236	-0.630	<.001	<.001	3	4
BRCA	FOXM1 →	-1.088	-0.588	<.001	.003	3	3
BRCA	TACC3 →	-0.825	-0.602	<.001	.003	3	3
BRCA	SLAMF8 →	-0.732	-0.490	<.001	.003	3	3
BRCA	LGALS7B →	-1.099	-0.478	<.001	<.001	3	3
BRCA	KIF18B →	-0.754	-0.555	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001759 vs SOAT1 — PDAC

Explore this scatter interactively →