Somitogenesis

Across TCGA patient cohorts, RNA activity of the Somitogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, ZNF318_S2101, and PSMB10_S230, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somitogenesis activity versus UPP1 in LSCC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UPP1 →	-0.485	-0.040	<.001	.001	3	6
GBM	ZNF318_S2101 →	+0.410	+0.051	<.001	<.001	3	6
GBM	PSMB10_S230 →	-0.381	-0.027	.006	.007	3	6
GBM	SAMSN1_S107 →	-0.441	-0.031	.004	.004	3	5
COAD	SPAG9_S332 →	-0.608	-0.042	<.001	<.001	3	5
PDAC	ADD3 →	+0.239	+0.031	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001756 vs UPP1 — LSCC

Explore this scatter interactively →