Somitogenesis

Across TCGA cell cohorts, RNA activity of the Somitogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRP14, MNS1, and ITGAV, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRP14 grouped by Somitogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SRP14 →	-0.468	-0.317	.007	.006	2	5
OESOPHAGUS	MNS1 →	-1.049	-0.240	.001	<.001	3	4
OVARY	ITGAV →	-1.122	-0.789	.001	.001	3	3
SOFT_TISSUE	ZNF385D →	-1.534	-0.957	.006	.009	3	3
BREAST	TPSG1 →	-0.510	-0.437	.007	.007	3	3
BREAST	SYTL2 →	-2.048	-0.554	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRP14 by Somitogenesis activity — OESOPHAGUS

Explore this box plot interactively →