Morphogenesis of a polarized epithelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of a polarized epithelium pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAP1, BIN2, and PLCB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a polarized epithelium activity versus TAP1 in HNSC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TAP1 →	-0.610	-0.062	<.001	<.001	3	9
LSCC	BIN2 →	-0.465	-0.046	<.001	<.001	3	8
HNSC	PLCB2 →	-0.375	-0.058	<.001	<.001	3	8
LSCC	SEC24A →	-0.308	-0.046	<.001	<.001	3	7
UCEC	TP53BP1 →	+0.262	+0.072	.001	<.001	3	7
UCEC	TP53BP1_T922 →	+0.471	+0.064	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001738 vs TAP1 — HNSC

Explore this scatter interactively →