Morphogenesis of a polarized epithelium

Across TCGA patient cohorts, RNA activity of the Morphogenesis of a polarized epithelium pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB3P32, LGALSL, and C16orf54, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a polarized epithelium activity versus HMGB3P32 in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMGB3P32 →	-0.568	-0.713	.008	.004	3	6
HNSC	LGALSL →	+0.802	+0.559	.006	.005	3	6
LSCC	C16orf54 →	-0.837	-0.857	<.001	.001	3	5
HNSC	PDCD1 →	-0.918	-0.648	<.001	.005	3	5
HNSC	LYL1 →	-0.834	-0.816	<.001	<.001	3	5
HNSC	CD6 →	-0.935	-0.885	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001738 vs HMGB3P32 — LSCC

Explore this scatter interactively →