Morphogenesis of a polarized epithelium

Across TCGA cell cohorts, RNA activity of the Morphogenesis of a polarized epithelium pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C9orf40, ERBIN, and MFSD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of a polarized epithelium activity versus C9orf40 in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C9orf40 →	+0.848	+0.176	.007	.006	3	5
LUNG_NSCLC_LUAD	ERBIN →	+0.844	+0.188	<.001	<.001	3	5
BONE	MFSD5 →	-0.474	-0.255	<.001	<.001	3	4
BLOOD_Myeloma	GALNS →	-1.495	-0.176	<.001	.001	3	4
LUNG_SCLC	MARVELD1 →	-1.183	-0.202	.004	.002	3	4
OESOPHAGUS	SH3YL1 →	-1.811	-0.195	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001738 vs C9orf40 — BREAST

Explore this scatter interactively →