Formation of translation preinitiation complex

Across TCGA patient cohorts, RNA activity of the Formation of translation preinitiation complex pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATRX, TCEAL1_S28, and TCEAL4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of translation preinitiation complex activity versus ATRX in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATRX →	+0.231	+0.038	.003	.003	3	7
HNSC	TCEAL1_S28 →	+0.352	+0.064	.008	.007	3	6
GBM	TCEAL4 →	+0.333	+0.031	<.001	.008	3	6
HNSC	RCOR3 →	+0.418	+0.078	<.001	<.001	3	5
LSCC	S100A8 →	-1.264	-0.049	<.001	<.001	3	5
BRCA	TCEAL1 →	+0.508	+0.027	.005	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001731 vs ATRX — COAD

Explore this scatter interactively →