Formation of translation preinitiation complex

Across TCGA pan-cancer cohorts, RNA activity of the Formation of translation preinitiation complex pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher Formation of translation preinitiation complex pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and PAAD, show the opposite pattern, with higher activity associated with better survival.

OV, KICH, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	IV	0.273	0.716	<.001	84	view →
KICH	DFS	Tertile	All	0.437	1.000	<.001	81	view →
KIRP	DFS	Median	All	0.785	0.930	<.001	50	view →
KIRC	DFS	Tertile	All	0.525	0.727	<.001	48	view →
UVM	DFS	Quartile	III,IV	0.095	1.000	.006	42	view →
ESCA	OS	Median	III,IV	0.608	0.308	.003	30	view →
PAAD	DFS	Quartile	II,III,IV	0.613	0.267	.004	27	view →
MESO	OS	Median	III,IV	0.450	0.256	.010	23	view →
HNSC	DFS	Median	IV	0.407	0.243	.004	23	view →
COAD	DFS	Median	All	0.734	0.826	.003	23	view →
PCPG	OS	Quartile	All	0.811	0.976	.011	13	view →
CESC	DFS	Median	All	0.765	0.871	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0001731–OV (DFS)

Open the OV breakdown →