Formation of translation preinitiation complex

Across TCGA patient cohorts, RNA activity of the Formation of translation preinitiation complex pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR1, FCGR3B, and CXCR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of translation preinitiation complex activity versus CXCR1 in PDAC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CXCR1 →	-0.922	-0.143	<.001	.003	3	6
PDAC	FCGR3B →	-1.606	-0.164	<.001	.001	3	5
PDAC	CXCR2 →	-0.837	-0.128	<.001	.006	3	5
PDAC	ADGRG3 →	-0.872	-0.186	<.001	<.001	3	4
HNSC	MEFV →	-0.786	-0.127	<.001	.001	3	4
PDAC	CMTM2 →	-0.454	-0.174	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001731 vs CXCR1 — PDAC

Explore this scatter interactively →