Formation of translation preinitiation complex

Across TCGA cell cohorts, RNA activity of the Formation of translation preinitiation complex pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECK, ANXA6, and CPNE8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RECK grouped by Formation of translation preinitiation complex-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RECK →	+1.600	+0.205	.005	.003	3	3
STOMACH	ANXA6 →	-2.803	-0.212	<.001	.001	3	3
LUNG_NSCLC_LUSC	CPNE8 →	+1.414	+0.247	<.001	.001	3	3
LUNG_NSCLC_LUSC	FCN3 →	+0.061	+0.206	.003	.003	3	3
LUNG_NSCLC_LUSC	HACD1 →	+1.638	+0.186	.008	.009	3	3
LUNG_NSCLC_LUSC	ZNF415 →	+2.512	+0.232	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RECK by Formation of translation preinitiation complex activity — OESOPHAGUS

Explore this box plot interactively →