Mesodermal cell fate commitment

Across TCGA cell cohorts, RNA activity of the Mesodermal cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC34, MORF4L1, and KIF9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC34 grouped by Mesodermal cell fate commitment-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDC34 →	-0.549	-0.782	<.001	.005	3	4
CNS	MORF4L1 →	+0.527	+1.132	.007	.001	3	4
BLOOD_Myeloma	KIF9 →	+0.677	+1.241	.002	<.001	3	4
OESOPHAGUS	PCBP4 →	-1.055	-0.829	.003	.003	3	4
SKIN	RNMT →	-0.632	-1.003	<.001	.002	3	4
BLOOD_Leukemia	MAP3K12 →	+0.864	+1.027	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC34 by Mesodermal cell fate commitment activity — OVARY

Explore this box plot interactively →