Cell fate specification

Across TCGA cell cohorts, RNA activity of the Cell fate specification pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCLS1, SOX17, and PLCD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HCLS1 grouped by Cell fate specification-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HCLS1 →	-0.146	-0.245	.003	<.001	2	6
LUNG_NSCLC_LUSC	SOX17 →	-0.198	-0.374	.009	.001	3	5
SOFT_TISSUE	PLCD3 →	-0.314	-0.291	.006	.005	3	5
LARGE_INTESTINE	ALDH5A1 →	-0.119	-0.190	.003	.001	3	4
LARGE_INTESTINE	WDR88 →	+0.153	+0.135	.003	.007	3	4
LUNG_NSCLC_LUAD	CD68 →	-0.147	-0.186	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HCLS1 by Cell fate specification activity — OVARY

Explore this box plot interactively →