Gastrulation with mouth forming second

Across TCGA patient cohorts, RNA activity of the Gastrulation with mouth forming second pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC1, ATIC, and RGL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastrulation with mouth forming second activity versus SIGLEC1 in UCEC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SIGLEC1 →	-0.745	-0.568	.001	.003	3	4
UCEC	ATIC →	-0.357	-0.613	.009	.006	3	4
UCEC	RGL1 →	+0.611	+0.892	.005	<.001	3	4
UCEC	CDC25B →	-0.761	-0.608	<.001	.009	3	4
UCEC	RCC2P4 →	-0.425	-0.542	.001	<.001	3	4
UCEC	BAMBI →	+1.270	+0.748	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001702 vs SIGLEC1 — UCEC

Explore this scatter interactively →