Gastric acid secretion

Across TCGA cell cohorts, RNA activity of the Gastric acid secretion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHKA2, PDGFD, and STRAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHKA2 grouped by Gastric acid secretion-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PHKA2 →	+0.903	+1.404	.009	<.001	3	4
BLOOD_Leukemia	PDGFD →	+1.059	+1.004	.009	.003	3	4
SKIN	STRAP →	+0.402	+0.951	<.001	<.001	3	4
PANCREAS	ZBTB17 →	+0.512	+1.104	.001	<.001	3	3
PANCREAS	ZNF224 →	+1.232	+1.503	<.001	<.001	3	3
URINARY_TRACT	EDEM1 →	+0.829	+1.408	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHKA2 by Gastric acid secretion activity — URINARY_TRACT

Explore this box plot interactively →