Histamine metabolic process

Across TCGA patient cohorts, RNA activity of the Histamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VRK1, CSTF3, and SMARCC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine metabolic process activity versus VRK1 in LSCC (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VRK1 →	-0.658	-0.114	<.001	<.001	3	5
HNSC	CSTF3 →	-0.239	-0.121	<.001	<.001	3	5
OV	SMARCC1 →	-0.335	-0.089	.001	.004	3	5
LUAD	SMC4 →	-0.397	-0.110	<.001	<.001	3	5
LSCC	SAMD1 →	-0.362	-0.104	.001	<.001	3	5
LSCC	SMC2 →	-0.424	-0.111	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001692 vs VRK1 — LSCC

Explore this scatter interactively →