Histamine metabolic process

Across TCGA patient cohorts, RNA activity of the Histamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV5-2, TRBV30, and PNOC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Histamine metabolic process activity versus IGKV5-2 in HNSC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGKV5-2 →	+2.092	+0.081	.004	.007	3	4
BRCA	TRBV30 →	+0.893	+0.820	.004	.005	3	4
LSCC	PNOC →	+0.420	+0.057	.002	.008	3	4
LSCC	IGKV2-24 →	+1.373	+0.089	.006	.003	3	4
LSCC	TMEM38A →	-0.708	-0.127	<.001	<.001	3	4
CCRCC	MS4A1 →	+0.785	+0.951	.002	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001692 vs IGKV5-2 — HNSC

Explore this scatter interactively →