tRNA 5'-leader removal

Across TCGA patient cohorts, RNA activity of the tRNA 5'-leader removal pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPP25, RIOK1, and RIF1_S2348, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 5'-leader removal activity versus RPP25 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPP25 →	+0.524	+0.039	.002	.002	3	8
COAD	RIOK1 →	+1.291	+0.078	.003	<.001	3	7
BRCA	RIF1_S2348 →	+1.130	+0.052	<.001	<.001	3	7
LSCC	DNMT1_S714 →	+0.831	+0.076	<.001	<.001	3	7
LUAD	FAM76B_T215 →	+1.131	+0.082	<.001	<.001	3	7
BRCA	KPNA2 →	+0.611	+0.038	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001682 vs RPP25 — GBM

Explore this scatter interactively →