tRNA 5'-leader removal

Across TCGA patient cohorts, RNA activity of the tRNA 5'-leader removal pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR62, NECTIN4, and EEF1AKMT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 5'-leader removal activity versus WDR62 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR62 →	+0.442	+0.092	.009	.002	3	4
LSCC	NECTIN4 →	+1.034	+0.165	<.001	<.001	3	4
LSCC	EEF1AKMT4 →	+0.751	+0.127	<.001	.005	3	4
LSCC	TLL1 →	-0.615	-0.171	<.001	<.001	3	4
BRCA	TFR2 →	+0.528	+0.160	.001	.009	3	3
BRCA	TMEM79 →	+0.405	+0.166	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001682 vs WDR62 — GBM

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