Intracellular glucose homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular glucose homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, TOP2A, and ZNF318_S709, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular glucose homeostasis activity versus RFC1_S368 in GBM (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC1_S368 →	-0.556	-0.030	<.001	<.001	3	5
GBM	TOP2A →	-0.496	-0.020	<.001	<.001	3	5
GBM	ZNF318_S709 →	-0.263	-0.025	.006	.001	3	5
LSCC	CARD19 →	+0.265	+0.031	<.001	<.001	3	5
GBM	DGCR8 →	-0.206	-0.021	<.001	<.001	3	4
LUAD	FOXM1_S522 →	-0.664	-0.023	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001678 vs RFC1_S368 — GBM

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