Intracellular glucose homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular glucose homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CT66, SERPINA4, and RSRC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular glucose homeostasis activity versus CT66 in OV (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CT66 →	+0.387	+0.170	.001	.005	3	3
CCRCC	SERPINA4 →	+0.635	+0.138	.001	.001	3	2
CCRCC	RSRC2 →	+0.186	+0.169	.006	.003	3	2
CCRCC	GCNA →	+0.357	+0.155	.003	.007	3	2
CCRCC	DIABLO →	+0.520	+0.183	<.001	<.001	3	2
CCRCC	RN7SKP75 →	+0.105	+0.199	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001678 vs CT66 — OV

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