Long-chain fatty acid metabolic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL27, IDH3A, and WDR18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid metabolic process activity versus RPL27 in PANCREAS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPL27 →	-0.816	-0.255	.006	.001	3	5
CNS	IDH3A →	+0.930	+0.250	.004	<.001	3	5
STOMACH	WDR18 →	-0.748	-0.278	.002	<.001	3	5
STOMACH	VSIR →	+2.138	+0.292	.004	.008	3	4
BLOOD_Myeloma	MRPS18B →	-1.069	-0.351	<.001	.002	3	4
LIVER	URM1 →	+0.754	+0.293	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001676 vs RPL27 — PANCREAS

Explore this scatter interactively →