Temperature homeostasis

Across TCGA patient cohorts, RNA activity of the Temperature homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24A, ZC4H2, and GMFG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Temperature homeostasis activity versus SEC24A in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEC24A →	+0.441	+0.131	.009	.006	3	3
LUAD	ZC4H2 →	-1.265	-0.419	.005	.002	3	3
CCRCC	GMFG →	-0.339	-0.160	.001	<.001	3	3
CCRCC	ELOCP2 →	+0.222	+0.150	.003	.001	3	3
CCRCC	ARHGAP15 →	-0.323	-0.102	.002	.005	3	3
LUAD	HOXC-AS2 →	+1.463	+0.366	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001659 vs SEC24A — CCRCC

Explore this scatter interactively →