Urogenital system development

Across TCGA patient cohorts, RNA activity of the Urogenital system development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF4, ITGBL1, and HMGB3P7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urogenital system development activity versus TCF4 in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TCF4 →	+0.522	+0.092	<.001	.006	3	5
BRCA	ITGBL1 →	+1.115	+0.170	<.001	<.001	3	5
BRCA	HMGB3P7 →	+0.614	+0.135	<.001	<.001	3	5
BRCA	LINC00702 →	+0.449	+0.135	<.001	<.001	3	5
GBM	GSC →	+0.796	+0.427	.001	.004	3	5
UCEC	EFS →	+0.912	+0.273	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001655 vs TCF4 — BRCA

Explore this scatter interactively →