Microtubule bundle formation

Across TCGA patient cohorts, RNA activity of the Microtubule bundle formation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP164, MDM1, and IFT81, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule bundle formation activity versus CEP164 in DLBC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	CEP164 →	+1.055	+0.034	<.001	<.001	3	29
DLBC	MDM1 →	+0.994	+0.020	<.001	<.001	3	29
UVM	IFT81 →	+1.174	+0.011	<.001	<.001	3	29
BRCA	WDR31 →	+0.854	+0.032	<.001	<.001	3	29
UCEC	CFAP157 →	+2.087	+0.092	<.001	<.001	3	29
KIRP	BBS1 →	+0.630	+0.044	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001578 vs CEP164 — DLBC

Explore this scatter interactively →