Ganglioside biosynthetic process

Across TCGA cell cohorts, RNA activity of the Ganglioside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC120, SUPT4H1, and GJA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC120 grouped by Ganglioside biosynthetic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC120 →	+1.509	+1.035	.001	.007	2	5
LUNG_NSCLC_LUSC	SUPT4H1 →	-0.725	-0.887	.003	.002	3	4
LUNG_NSCLC_LUAD	GJA1 →	-3.887	-0.530	<.001	.003	3	3
BREAST	CHMP4C →	+1.066	+0.673	.002	.002	3	3
BLOOD_Leukemia	COPS9 →	-0.870	-1.211	.001	.001	3	3
SKIN	WDR12 →	-0.693	-1.061	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC120 by Ganglioside biosynthetic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →