Branching involved in blood vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Branching involved in blood vessel morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, PCOLCE, and AEBP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branching involved in blood vessel morphogenesis activity versus COL3A1 in OV (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL3A1 →	+1.069	+0.108	<.001	<.001	3	9
OV	PCOLCE →	+0.993	+0.087	<.001	<.001	3	9
CCRCC	AEBP1 →	+0.862	+0.047	<.001	.003	3	9
UCEC	EFEMP2 →	+0.662	+0.057	<.001	<.001	3	9
UCEC	SVIL_S467 →	+0.831	+0.064	<.001	<.001	3	8
OV	GSN →	+0.795	+0.083	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001569 vs COL3A1 — OV

Explore this scatter interactively →