Branching involved in blood vessel morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Branching involved in blood vessel morphogenesis pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 36 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Branching involved in blood vessel morphogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LUAD, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRP, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.350	0.735	<.001	135	view →
KIRP	OS	Median	All	0.581	0.788	<.001	108	view →
HNSC	DFS	Median	IV	0.458	0.296	<.001	84	view →
MESO	OS	Median	II,III,IV	0.289	0.513	.002	43	view →
COAD	DFS	Tertile	All	0.376	0.597	.003	43	view →
LGG	DFS	Median	All	0.288	0.462	<.001	43	view →
KICH	DFS	Median	III,IV	0.373	1.000	.009	41	view →
THCA	OS	Tertile	II,III,IV	0.945	1.000	<.001	40	view →
LUAD	DFS	Tertile	II,III,IV	0.712	0.313	<.001	37	view →
ACC	DFS	Quartile	II,III,IV	0.487	0.856	.009	22	view →
OV	OS	Quartile	All	0.278	0.394	.015	20	view →
KIRC	DFS	Tertile	All	0.507	0.688	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0001569–UVM (DFS)

Open the UVM breakdown →