Branching involved in blood vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Branching involved in blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT19, THG1L, and DCLK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branching involved in blood vessel morphogenesis activity versus KRT19 in LUAD (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KRT19 →	-0.805	-0.179	.004	.005	2	5
OV	THG1L →	+0.556	+0.167	.003	.002	3	3
BRCA	DCLK3 →	+0.208	+0.168	.004	.002	3	3
BRCA	MSL2 →	+0.275	+0.136	.002	<.001	3	3
BRCA	KANK2 →	+0.638	+0.154	.004	.004	3	3
BRCA	SCARNA8 →	+0.579	+0.145	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001569 vs KRT19 — LUAD

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