Branching involved in blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Branching involved in blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD8, CRISPLD2, and SMG9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEDD8 grouped by Branching involved in blood vessel morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NEDD8 →	-0.639	-0.983	.008	.001	3	4
SKIN	CRISPLD2 →	-0.962	-1.102	.005	<.001	3	3
LUNG_SCLC	SMG9 →	-1.240	-1.302	.001	.004	3	3
SKIN	RGS9 →	-0.606	-0.836	.004	<.001	3	3
LUNG_SCLC	TTLL5 →	-0.740	-1.224	.001	<.001	3	3
SKIN	HIVEP3 →	-1.218	-1.012	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEDD8 by Branching involved in blood vessel morphogenesis activity — OVARY

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