Branching involved in blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Branching involved in blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A6, ANKRD50, and TNRC6C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branching involved in blood vessel morphogenesis activity versus SLC12A6 in BLOOD_Lymphoma (Pearson r = 0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC12A6 →	+3.110	+0.274	.006	.007	3	3
BLOOD_Lymphoma	ANKRD50 →	+3.445	+0.274	<.001	.007	3	3
BLOOD_Lymphoma	TNRC6C →	+2.440	+0.274	.005	.007	3	3
BLOOD_Leukemia	SEPTIN3 →	-3.006	-1.764	<.001	.007	3	3
OVARY	MOV10 →	-0.738	-1.463	.003	.001	3	3
OVARY	SPAG17 →	-1.332	-1.492	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001569 vs SLC12A6 — BLOOD_Lymphoma

Explore this scatter interactively →