Response to protozoan

Across TCGA patient cohorts, RNA activity of the Response to protozoan pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00426, LINC00861, and TRG-AS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to protozoan activity versus LINC00426 in CCRCC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LINC00426 →	+1.211	+1.208	<.001	<.001	3	9
BRCA	LINC00861 →	+0.833	+0.754	<.001	<.001	3	8
CCRCC	TRG-AS1 →	+0.746	+0.941	<.001	<.001	3	8
BRCA	S1PR4 →	+0.951	+0.837	<.001	<.001	3	8
GBM	PIK3R5 →	+0.979	+0.712	<.001	<.001	3	8
CCRCC	CD3G →	+1.288	+1.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001562 vs LINC00426 — CCRCC

Explore this scatter interactively →