Luteinization

Across TCGA cell cohorts, RNA activity of the Luteinization pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX4I1, ACAD9, and CPNE6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX4I1 grouped by Luteinization-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX4I1 →	-0.230	-0.969	.001	<.001	3	6
BREAST	ACAD9 →	-0.231	-0.913	.005	.007	3	5
OVARY	CPNE6 →	+0.172	+0.939	<.001	.009	3	4
OVARY	HCCS →	-0.322	-1.444	.008	.002	3	4
SOFT_TISSUE	HPD →	+0.282	+1.862	.006	<.001	3	4
OESOPHAGUS	FUT1 →	-0.211	-1.324	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX4I1 by Luteinization activity — BREAST

Explore this box plot interactively →