Cilium or flagellum-dependent cell motility

Across TCGA patient cohorts, RNA activity of the Cilium or flagellum-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA4, AK9, and CCDC30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cilium or flagellum-dependent cell motility activity versus SPATA4 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPATA4 →	+0.482	+0.628	<.001	<.001	3	4
OV	AK9 →	+0.422	+0.688	.003	.005	3	4
LSCC	CCDC30 →	+0.294	+0.791	<.001	.003	3	4
LUAD	CFAP69 →	+0.351	+0.729	.005	.005	3	4
CCRCC	SLC30A4 →	+0.231	+0.355	<.001	.003	3	3
UCEC	PEX11B →	+0.356	+0.902	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001539 vs SPATA4 — BRCA

Explore this scatter interactively →