Pseudouridine synthesis

Across TCGA cell cohorts, RNA activity of the Pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A8, TMEM87B, and PRR15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC2A8 grouped by Pseudouridine synthesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC2A8 →	+0.947	+0.238	.001	.004	3	4
KIDNEY	TMEM87B →	+1.022	+0.359	.003	.005	3	4
BREAST	PRR15 →	+1.985	+0.260	.003	.001	3	4
LUNG_SCLC	SMC4 →	-1.103	-0.327	.005	.009	3	3
LUNG_SCLC	NBL1 →	+2.247	+0.303	<.001	.002	3	3
LUNG_SCLC	BCLAF3 →	-0.996	-0.394	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC2A8 by Pseudouridine synthesis activity — BREAST

Explore this box plot interactively →