Action potential

Across TCGA patient cohorts, RNA activity of the Action potential pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GART, NID1, and NID2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Action potential activity versus GART in OV (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GART →	-0.383	-0.019	.001	.006	3	7
BRCA	NID1 →	+0.466	+0.021	<.001	<.001	3	7
BRCA	NID2 →	+0.451	+0.025	.001	<.001	3	7
GBM	SH3PXD2A →	+0.437	+0.070	<.001	<.001	3	7
PDAC	REEP4_S152 →	-0.760	-0.024	.001	.001	3	7
CCRCC	TNS2 →	+0.290	+0.018	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001508 vs GART — OV

Explore this scatter interactively →