Cartilage condensation

Across TCGA patient cohorts, RNA activity of the Cartilage condensation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNDIG1, SGIP1, and APBB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cartilage condensation activity versus SYNDIG1 in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNDIG1 →	+0.860	+0.289	.009	.006	3	6
OV	SGIP1 →	+0.322	+0.476	.007	.005	3	6
HNSC	APBB2 →	+0.378	+0.205	.007	.003	3	5
LSCC	PLPP4 →	+1.050	+0.532	<.001	<.001	3	5
LSCC	MFAP2 →	+0.493	+0.306	.002	.004	3	5
LSCC	TAGLN →	+0.688	+0.288	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001502 vs SYNDIG1 — HNSC

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