Cartilage condensation

Across TCGA pan-cancer cohorts, RNA activity of the Cartilage condensation pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Cartilage condensation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and THCA, show the opposite pattern, with higher activity associated with better survival.

KICH, KIRP, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.553	1.000	.001	73	view →
KIRP	OS	Quartile	All	1.000	0.874	.001	65	view →
PAAD	DFS	Tertile	All	0.159	0.426	.001	42	view →
LGG	OS	Tertile	All	0.381	0.585	<.001	35	view →
SCLC	OS	Median	III,IV	0.471	0.765	.006	33	view →
KIRC	DFS	Tertile	II,III,IV	0.396	0.624	.002	33	view →
BLCA	OS	Median	All	0.350	0.562	.001	32	view →
THCA	OS	Tertile	All	1.000	0.897	.003	28	view →
DLBC	OS	Median	All	0.796	1.000	.004	24	view →
LAML	DFS	Tertile	All	0.467	0.646	.021	14	view →
BRCA	DFS	Median	II,III,IV	0.858	0.911	.009	11	view →
PCPG	DFS	Tertile	All	0.978	0.803	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0001502–KICH (OS)

Open the KICH breakdown →