Cartilage condensation

Across TCGA cell cohorts, RNA activity of the Cartilage condensation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGLL1, NPEPL1, and PTOV1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGLL1 grouped by Cartilage condensation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IGLL1 →	+0.196	+0.924	.005	.003	3	4
LUNG_NSCLC_LUSC	NPEPL1 →	-1.418	-1.531	.006	<.001	3	4
LUNG_SCLC	PTOV1 →	-0.736	-1.134	.001	.001	3	4
LIVER	ABCC4 →	+2.358	+2.066	<.001	<.001	3	4
LUNG_SCLC	ZNF665 →	-1.737	-1.049	.003	.009	3	4
OESOPHAGUS	SASH3 →	+0.249	+0.975	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGLL1 by Cartilage condensation activity — PANCREAS

Explore this box plot interactively →