Formation of extrachromosomal circular DNA

Across TCGA cell cohorts, RNA activity of the Formation of extrachromosomal circular DNA pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMUG1, GP1BA, and CIAO3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Formation of extrachromosomal circular DNA activity versus SMUG1 in LUNG_SCLC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SMUG1 →	+0.939	+0.314	<.001	.004	2	3
KIDNEY	GP1BA →	+0.892	+0.288	.001	<.001	3	2
KIDNEY	CIAO3 →	+1.017	+0.288	.002	<.001	3	2
KIDNEY	RAPGEFL1 →	+0.939	+0.288	.002	<.001	3	2
KIDNEY	FCSK →	+0.984	+0.288	.003	<.001	3	2
KIDNEY	CASKIN2 →	+1.127	+0.288	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001325 vs SMUG1 — LUNG_SCLC

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