Response to acid chemical

Across TCGA cell cohorts, RNA activity of the Response to acid chemical pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1, ATP6V1E1, and ARHGAP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to acid chemical activity versus STUB1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	STUB1 →	+0.942	+0.198	.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	ATP6V1E1 →	+1.229	+0.176	<.001	.004	3	8
OVARY	ARHGAP1 →	+1.170	+0.166	.002	.001	3	8
SKIN	ERH →	-0.458	-0.147	<.001	<.001	3	7
STOMACH	HNRNPR →	-0.527	-0.181	.004	.001	3	7
OVARY	CSTB →	+2.373	+0.215	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001101 vs STUB1 — UPPER_AERODIGESTIVE_TRACT

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