Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

pathway activity — cross-omics
GO:0000972Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSH6, TOP2A, and CSE1L, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity versus MSH6 in LSCC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCMSH6 →+0.781+0.076<.001<.001310
LUADTOP2A →+0.911+0.083<.001<.00139
LSCCCSE1L →+0.298+0.057<.001<.00139
PDACTPX2 →+0.685+0.055<.001<.00139
LSCCRFC2 →+0.310+0.055<.001<.00139
LSCCMSH2 →+0.684+0.082<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000972 vs MSH6 — LSCC

Per-sample scatter of Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery activity vs MSH6 in LSCC.

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Exploration