RNA 5'-end processing

Across TCGA patient cohorts, RNA activity of the RNA 5'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, NPM1_S254, and NPM1_T199, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 5'-end processing activity versus RFC5 in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.395	+0.066	<.001	<.001	3	8
LUAD	NPM1_S254 →	+1.099	+0.051	<.001	<.001	3	8
LUAD	NPM1_T199 →	+1.410	+0.043	<.001	<.001	3	8
BRCA	DDX21 →	+0.704	+0.042	<.001	<.001	3	8
LSCC	RFC4 →	+0.321	+0.038	<.001	<.001	3	7
BRCA	SRPK1 →	+0.418	+0.034	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000966 vs RFC5 — LSCC

Explore this scatter interactively →