Mitochondrial RNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNHG29, ELAC2, and LMOD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA 3'-end processing activity versus SNHG29 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNHG29 →	+0.604	+0.125	.001	.001	3	5
OV	ELAC2 →	+0.457	+0.088	.006	<.001	3	5
COAD	LMOD1 →	-1.301	-0.149	<.001	<.001	3	5
BRCA	CNRIP1 →	-0.617	-0.139	.003	<.001	3	5
PDAC	LINC00702 →	-0.666	-0.121	<.001	<.001	3	5
LSCC	TWNK →	+0.621	+0.174	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000965 vs SNHG29 — LUAD

Explore this scatter interactively →