Mitochondrial RNA processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial RNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUPT16H, SSRP1, and DDX56, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial RNA processing activity versus SUPT16H in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUPT16H →	+0.386	+0.051	<.001	<.001	3	8
LSCC	SSRP1 →	+0.444	+0.057	<.001	<.001	3	7
LSCC	DDX56 →	+0.298	+0.039	<.001	<.001	3	7
LSCC	UTP15 →	+0.277	+0.045	<.001	<.001	3	7
OV	WDR89 →	+0.288	+0.035	<.001	<.001	3	7
LUAD	CPSF3 →	+0.210	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000963 vs SUPT16H — LSCC

Explore this scatter interactively →