DNA double-strand break processing

Across TCGA patient cohorts, RNA activity of the DNA double-strand break processing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RERE_S642, RFC3, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA double-strand break processing activity versus RERE_S642 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RERE_S642 →	+0.593	+0.063	<.001	<.001	3	10
LSCC	RFC3 →	+0.459	+0.097	<.001	<.001	3	10
LUAD	SMC4 →	+0.553	+0.066	<.001	<.001	3	10
GBM	DDX42 →	+0.246	+0.073	.007	.001	3	10
UCEC	RFC1_T506 →	+0.997	+0.082	<.001	<.001	3	9
PDAC	RFC2 →	+0.349	+0.053	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000729 vs RERE_S642 — UCEC

Explore this scatter interactively →