Double-strand break repair via break-induced replication

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via break-induced replication pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RFC2, and RFC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via break-induced replication activity versus RFC1_T506 in LUAD (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.366	+0.168	<.001	<.001	3	10
HNSC	RFC2 →	+0.494	+0.121	<.001	<.001	3	10
HNSC	RFC4 →	+0.555	+0.126	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.224	+0.151	<.001	<.001	3	10
UCEC	RRM1 →	+0.647	+0.136	<.001	<.001	3	10
LUAD	RRM2 →	+1.016	+0.159	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000727 vs RFC1_T506 — LUAD

Explore this scatter interactively →