Telomere maintenance

Across TCGA patient cohorts, RNA activity of the Telomere maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and VRK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance activity versus SMC2 in LSCC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.765	+0.061	<.001	<.001	3	8
LUAD	SMC4 →	+0.528	+0.040	<.001	<.001	3	8
LSCC	VRK1 →	+0.523	+0.055	<.001	<.001	3	8
COAD	CHEK1 →	+0.684	+0.030	<.001	<.001	3	8
LUAD	MCM2 →	+0.720	+0.046	<.001	<.001	3	8
LUAD	MCM2_S139 →	+0.863	+0.040	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0000723 vs SMC2 — LSCC

Explore this scatter interactively →